Lab Publications with PubMed Links

  • PEPTERGENT: A Peptide-Based Reagent for Detergent-Free Extraction of Membrane Proteins and Purification of Membrane Proteomes (2026). Antony F, Bhattacharya A, Duong van Hoa F. Bio Protoc. 2026 May 20;16(10):e5700. doi: 10.21769/BioProtoc.5700. PubMed

  • Membrane Proteome Remodeling in Female APP/PS1 Mice Following M1 Muscarinic Receptor Modulation Revealed by Peptidisc-Enabled DIA-MS (2026). Bhattacharya A, Antony F, Aoki H, Babu M, Ferguson SSG, Abd-Elrahman KS, Duong van Hoa F. J Proteome Res. 2026 Jun 5;25(6):3136-3148. doi: 10.1021/acs.jproteome.6c00140. PubMed

  • Comparative Evaluation of Solid-phase and Membrane Mimetic Strategies in Membrane Proteome Coverage and Disease-State Analysis (2026). Antony F, Bhattacharya A, Aoki H, Jandu RS, Abdualkader AM, Al Batran R, Babu M, Duong van Hoa F. Mol Cell Proteomics. 2026 Feb;25(2):101496. doi: 10.1016/j.mcpro.2025.101496. PubMed

  • Membrane-mimetic thermal proteome profiling (MM-TPP) toward mapping membrane protein-ligand dynamic interactions (2025). Jandu RS, Bhattacharya A, Antony F, Al-Seragi M, Aoki H, Babu M, Duong van Hoa F. Elife. 2025 Nov 12;14:RP104549. doi: 10.7554/eLife.104549. PubMed

  • Expanding the Reach of Membrane Protein-Ligand Interaction Studies Through the Integration of Mass Spectrometry and Membrane Mimetics (2025). Lambos JC, Bhattacharya A, Al-Seragi M, Duong van Hoa F. Proteomics. 2025 Nov;25(21-22):25-40. doi: 10.1002/pmic.70057. PubMed

  • YibN, a bona fide interactor of the bacterial YidC insertase with effects on membrane protein insertion and membrane lipid production (2025). Zhao Z, Yamamoto N, Young JW, Solis N, Fong A, Al-Seragi M, Kim S, Aoki H, Phanse S, Le HT, Overall CM, Nishikawa H, Babu M, Nishiyama KI, Duong van Hoa F. J Biol Chem. 2025 Apr;301(4):108395. doi: 10.1016/j.jbc.2025.108395. PubMed

  • Advances in nanobody multimerization and multispecificity: from in vivo assembly to in vitro production (2025). Al-Seragi M, Chen Y, Duong van Hoa F. Biochem Soc Trans. 2025 Feb 7;53(1):235-48. doi: 10.1042/BST20241419. PubMed

  • Peptidisc-Assisted Hydrophobic Clustering Toward the Production of Multimeric and Multispecific Nanobody Proteins (2025). Chen Y, Duong van Hoa F. Biochemistry. 2025 Feb 4;64(3):655-665. doi: 10.1021/acs.biochem.4c00793. PubMed

  • Sensitive Profiling of Mouse Liver Membrane Proteome Dysregulation Following a High-Fat and Alcohol Diet Treatment (2024). Antony F, Brough Z, Orangi M, Al-Seragi M, Aoki H, Babu M, Duong van Hoa F. Proteomics. 2024 Dec;24(23-24):e202300599. doi: 10.1002/pmic.202300599. PubMed

  • From bottom-up to cell surface proteomics: detergents or no detergents, that is the question (2024). Brough Z, Zhao Z, Duong van Hoa F. Biochem Soc Trans. 2024 Jun 26;52(3):1253-1263. doi: 10.1042/BST20231020. PubMed

  • Capture of endogenous lipids in peptidiscs and effect on protein stability and activity (2024). Jandu RS, Yu H, Zhao Z, Le HT, Kim S, Huan T, Duong van Hoa F. iScience. 2024 Mar 1;27(4):109382. doi: 10.1016/j.isci.2024.109382. PubMed

  • Affinity Purification of Membrane β-Barrel Proteins via Biotin-Tagged Peptidiscs (2024). Zhao Z, Young JW, Duong van Hoa F. Methods Mol Biol. 2024;2778:147-158. doi: 10.1007/978-1-0716-3734-0_10. PubMed

  • Capture of the Mouse Organ Membrane Proteome Specificity in Peptidisc Libraries (2024). Antony F, Brough Z, Zhao Z, Duong van Hoa F. J Proteome Res. 2024 Feb 2;23(2):857-867. doi: 10.1021/acs.jproteome.3c00825. PubMed

  • A Peptidisc-Based Survey of the Plasma Membrane Proteome of a Mammalian Cell (2023). Zhao Z, Khurana A, Antony F, Young JW, Hewton KG, Brough Z, Zhong T, Parker SJ, Duong van Hoa F. Mol Cell Proteomics. 2023 Aug;22(8):100588. doi: 10.1016/j.mcpro.2023.100588. PubMed

  • A Dual Detergent Strategy to Capture a Bacterial Outer Membrane Proteome in Peptidiscs for Characterization by Mass Spectrometry and Binding Assays (2023). Young JW, Zhao Z, Wason IS, Duong van Hoa F. J Proteome Res. 2023 May 5;22(5):1537-1545. doi: 10.1021/acs.jproteome.2c00560. PubMed

  • Development of a Method Combining Peptidiscs and Proteomics to Identify, Stabilize, and Purify a Detergent-Sensitive Membrane Protein Assembly (2022). Young JW, Wason IS, Zhao Z, Kim S, Aoki H, Phanse S, Rattray DG, Foster LJ, Babu M, Duong van Hoa F. J Proteome Res. 2022 Jul 1;21(7):1748-1758. doi: 10.1021/acs.jproteome.2c00129. PubMed

  • Structural Dynamics of the Functional Nonameric Type III Translocase Export Gate (2021). Yuan B, Portaliou AG, Parakra R, Smit JH, Wald J, Li Y, Srinivasu B, Loos MS, Dhupar HS, Fahrenkamp D, Kalodimos CG, Duong van Hoa F, Cordes T, Karamanou S, Marlovits TC, Economou A. J Mol Biol. 2021 Oct 15;433(21):167188. doi: 10.1016/j.jmb.2021.167188. PubMed

  • Structural and functional diversity calls for a new classification of ABC transporters (2020). Thomas C, Aller SG, Beis K, Carpenter EP, Chang G, Chen L, Dassa E, Dean M, Duong Van Hoa F, Ekiert D, Ford R, Gaudet R, Gong X, Holland IB, Huang Y, Kahne DK, Kato H, Koronakis V, Koth CM, Lee Y, Lewinson O, Lill R, Martinoia E, Murakami S, Pinkett HW, Poolman B, Rosenbaum D, Sarkadi B, Schmitt L, Schneider E, Shi Y, Shyng SL, Slotboom DJ, Tajkhorshid E, Tieleman DP, Ueda K, Váradi A, Wen PC, Yan N, Zhang P, Zheng H, Zimmer J, Tampé R. FEBS Lett. 2020 Dec;594(23):3767-3775. doi: 10.1002/1873-3468.13935. PubMed

  • Correction to: A Mathematical Model for the Kinetics of the MalFGK2 Maltose Transporter (2020). Hiller RM, von Kügelgen J, Bao H, Duong Van Hoa F, Cytrynbaum EN. Bull Math Biol. 2020 Jul 11;82(7):92. doi: 10.1007/s11538-020-00772-5. PubMed

  • His-Tagged Peptidiscs Enable Affinity Purification of the Membrane Proteome for Downstream Mass Spectrometry Analysis (2020). Young JW, Wason IS, Zhao Z, Rattray DG, Foster LJ, Duong Van Hoa F. J Proteome Res. 2020 Jul 2;19(7):2553-2562. doi: 10.1021/acs.jproteome.0c00022. PubMed

  • New approach for membrane protein reconstitution into peptidiscs and basis for their adaptability to different proteins (2020). Angiulli G, Dhupar HS, Suzuki H, Wason IS, Duong Van Hoa F, Walz T. Elife. 2020 Mar 3;9:e53530. doi: 10.7554/eLife.53530. PubMed

  • PeptiQuick, a One-Step Incorporation of Membrane Proteins into Biotinylated Peptidiscs for Streamlined Protein Binding Assays (2019). Saville JW, Troman LA, Duong Van Hoa F. J Vis Exp. 2019 Nov 2;(153). doi: 10.3791/60661. PubMed

  • Profiling the Escherichia coli membrane protein interactome captured in Peptidisc libraries (2019). Carlson ML, Stacey RG, Young JW, Wason IS, Zhao Z, Rattray DG, Scott N, Kerr CH, Babu M, Foster LJ, Duong Van Hoa F. Elife. 2019 Jul 31;8:e46615. doi: 10.7554/eLife.46615. PubMed

  • Nanodisc-Based Proteomics Identify Caj1 as an Hsp40 with Affinity for Phosphatidic Acid Lipids (2021). Zhang XX, Young JW, Foster LJ, Duong F. J Proteome Res. 2021 Oct 1;20(10):4831-4839. doi: 10.1021/acs.jproteome.1c00503. PubMed

  • Investigating the stability of the SecA-SecYEG complex during protein translocation across the bacterial membrane (2019). Young J, Duong F. J Biol Chem. 2019 Mar 8;294(10):3577-3587. doi: 10.1074/jbc.RA118.006447. PubMed

  • Selectively targeting the dimerization interface of human androgen receptor with small-molecules to treat castration-resistant prostate cancer (2018). Dalal K, Ban F, Li H, Morin H, Roshan-Moniri M, Tam KJ, Shepherd A, Sharma A, Peacock J, Carlson ML, LeBlanc E, Perez C, Duong F, Ong CJ, Rennie PS, Cherkasov A. Cancer Lett. 2018 Nov 28;437:35-43. doi: 10.1016/j.canlet.2018.08.016. PubMed

  • The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution (2018). Carlson ML, Young JW, Zhao Z, Fabre L, Jun D, Li J, Li J, Dhupar HS, Wason I, Mills AT, Beatty JT, Klassen JS, Rouiller I, Duong F. Elife. 2018 Aug 15;7:e34085. doi: 10.7554/eLife.34085. PubMed

  • Lipopolysaccharides promote binding and unfolding of the antibacterial colicin E3 rRNAse domain (2017). Mills A, Duong F. Biochim Biophys Acta Biomembr. 2017 Dec;1859(12):2454-2460. doi: 10.1016/j.bbamem.2017.08.022. PubMed

  • Negative Stain Single-particle EM of the Maltose Transporter in Nanodiscs Reveals Asymmetric Closure of MalK2 and Catalytic Roles of ATP, MalE, and Maltose (2017). Fabre L, Bao H, Innes J, Duong F, Rouiller I. J Biol Chem. 2017 Mar 31;292(13):5457-5464. doi: 10.1074/jbc.M116.757898. PubMed

  • TonB-dependent ligand trapping in the BtuB transporter (2016). Mills A, Le HT, Duong F. Biochim Biophys Acta. 2016 Dec;1858(12):3105-3112. doi: 10.1016/j.bbamem.2016.09.019. PubMed

  • Salmonella Rapidly Regulates Membrane Permeability To Survive Oxidative Stress (2016). van der Heijden J, Reynolds LA, Deng W, Mills A, Scholz R, Imami K, Foster LJ, Duong F, Finlay BB. mBio. 2016 Aug 9;7(4):e01238-16. doi: 10.1128/mBio.01238-16. PubMed

  • Formation of a Chloride-conducting State in the Maltose ATP-binding Cassette (ABC) Transporter (2016). Carlson ML, Bao H, Duong F. J Biol Chem. 2016 Jun 3;291(23):12119-25. doi: 10.1074/jbc.M115.711622. PubMed

  • Sequential Action of MalE and Maltose Allows Coupling ATP Hydrolysis to Translocation in the MalFGK2 Transporter (2015). Bao H, Dalal K, Cytrynbaum E, Duong F. J Biol Chem. 2015 Oct 16;290(42):25452-60. doi: 10.1074/jbc.M115.671826. PubMed

  • Capturing the bacterial holo-complex (2014). Duong F. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4739-40. doi: 10.1073/pnas.1402139111. PubMed

  • Nucleotide-free MalK drives the transition of the maltose transporter to the inward-facing conformation (2014). Bao H, Duong F. J Biol Chem. 2014 Apr 4;289(14):9844-51. doi: 10.1074/jbc.M113.545525. PubMed

  • FhuA interactions in a detergent-free nanodisc environment (2014). Mills A, Le HT, Coulton JW, Duong F. Biochim Biophys Acta. 2014 Jan;1838(1 Pt B):364-71. doi: 10.1016/j.bbamem.2013.09.022. PubMed

  • Phosphatidylglycerol directs binding and inhibitory action of EIIAGlc protein on the maltose transporter (2013). Bao H, Duong F. J Biol Chem. 2013 Aug 16;288(33):23666-74. doi: 10.1074/jbc.M113.489567. PubMed

  • The maltose ABC transporter: action of membrane lipids on the transporter stability, coupling and ATPase activity (2013). Bao H, Dalal K, Wang V, Rouiller I, Duong F. Biochim Biophys Acta. 2013 Aug;1828(8):1723-30. doi: 10.1016/j.bbamem.2013.03.024. PubMed

  • SecYEG activates GTPases to drive the completion of cotranslational protein targeting (2013). Akopian D, Dalal K, Shen K, Duong F, Shan SO. J Cell Biol. 2013 Feb 18;200(4):397-405. doi: 10.1083/jcb.201208045. PubMed

  • ATP alone triggers the outward-facing conformation of the maltose ATP-binding cassette transporter (2013). Bao H, Duong F. J Biol Chem. 2013 Feb 1;288(5):3439-48. doi: 10.1074/jbc.M112.431932. PubMed

  • A step-by-step method for the reconstitution of an ABC transporter into nanodisc lipid particles (2012). Bao H, Duong F, Chan CS. J Vis Exp. 2012 Aug 31;(66):e3910. doi: 10.3791/3910. PubMed

  • Discovery of an auto-regulation mechanism for the maltose ABC transporter MalFGK2 (2012). Bao H, Duong F. PLoS One. 2012;7(4):e34836. doi: 10.1371/journal.pone.0034836. PubMed

  • Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling (2012). Fonseca BD, Diering GH, Bidinosti MA, Dalal K, Alain T, Balgi AD, Forestieri R, Nodwell M, Rajadurai CV, Gunaratnam C, Tee AR, Duong F, Andersen RJ, Orlowski J, Numata M, Sonenberg N, Roberge M. J Biol Chem. 2012 May 18;287(21):17530-17545. doi: 10.1074/jbc.M112.359638. PubMed

  • Two copies of the SecY channel and acidic lipids are necessary to activate the SecA translocation ATPase (2012). Dalal K, Chan CS, Sligar SG, Duong F. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4104-9. doi: 10.1073/pnas.1117783109. PubMed

  • Nanodiscs and SILAC-based mass spectrometry to identify a membrane protein interactome (2012). Zhang XX, Chan CS, Bao H, Fang Y, Foster LJ, Duong F. J Proteome Res. 2012 Feb 3;11(2):1454-9. doi: 10.1021/pr200846y. PubMed

  • The SecY complex: conducting the orchestra of protein translocation (2011). Dalal K, Duong F. Trends Cell Biol. 2011 Sep;21(9):506-14. doi: 10.1016/j.tcb.2011.04.005. PubMed

  • The action of cardiolipin on the bacterial translocon (2010). Gold VA, Robson A, Bao H, Romantsov T, Duong F, Collinson I. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10044-9. doi: 10.1073/pnas.0914680107. PubMed

  • Reconstitution of the SecY translocon in nanodiscs (2010). Dalal K, Duong F. Methods Mol Biol. 2010;619:145-56. doi: 10.1007/978-1-60327-412-8_9. PubMed

  • Modulation of the SecY channel permeability by pore mutations and trivalent cations (2010). Dalal K, Bao H, Duong F. Channels (Austin). 2010 Mar-Apr;4(2):83-6. doi: 10.4161/chan.4.2.10533. PubMed

  • The SecY complex forms a channel capable of ionic discrimination (2009). Dalal K, Duong F. EMBO Rep. 2009 Jul;10(7):762-8. doi: 10.1038/embor.2009.87. PubMed

  • Structure, binding, and activity of Syd, a SecY-interacting protein (2009). Dalal K, Nguyen N, Alami M, Tan J, Moraes TF, Lee WC, Maurus R, Sligar SS, Brayer GD, Duong F. J Biol Chem. 2009 Mar 20;284(12):7897-902. doi: 10.1074/jbc.M808305200. PubMed

  • Structure and function of the bacterial Sec translocon (2007). Gold VA, Duong F, Collinson I. Mol Membr Biol. 2007 Sep-Dec;24(5-6):387-94. doi: 10.1080/09687680701416570. PubMed

  • Cell biology: fraternal twins (2007). Duong F. Nature. 2007 Apr 12;446(7137):741-3. doi: 10.1038/446741a. PubMed